Bernthal's first major film role was in the Oliver Stone picture, World Trade Center with Nicholas Cage and Maria Bello. He has also starred in Date Night, with Steve Carell and Tina Fey; in Roman Polanski's award-winning The Ghost Writer, opposite Ewan McGregor; Night at the Museum: Battle of the Smithsonian opposite Ben Stiller and Christopher Guest and Hank Azaria; and the independent films The Air I Breathe with Kevin Bacon and Julie Delpy, and Day Zero with Elijah Wood. In television, Bernthal was recently part of the ensemble in the Tom Hanks and Steven Spielberg HBO miniseries, The Pacific. In film, he recently completed production on Oren Moverman's Rampart, where he co-stars opposite Woody Harrelson, Steve Buscemi, Robin Wright and Sigourney Weaver.
Alongside his father, Bernthal has launched a production company with several film and television projects in development.
During his college years, Bernthal was given the remarkable opportunity to study the prestigious Moscow Arts Theatre in Russia, where he graduated with a Master of Fine Arts.
Bernthal, a veteran of more than 30 productions, recently returned to his roots in the Rogue Machine Theatre's production of Small Engine Repair, where he starred as Terrance Swaino. His love of theatre led him to open his own non-profit theatre company Fovea Floods, in upstate New York.
Bernthal was a professional baseball player both in the U.S. minor leagues and European Professional Baseball Federation. These days, Bernthal prefers boxing where he has trained for years and boxes six days a week. He also teaches boxing to at risk children to teach them discipline and work ethic, leading them to channel their issues into a sport which teaches them confidence and control. Bernthal also works to retrain pit bulls that have been abused, then placing them in new, loving homes. Bernthal lives with his wife Erin, their son, and their dogs, Boss and Venice.